Overview of novel coronavirus infection and replication.

Author: Lihong HE ¹ ; Wenjun LIU ¹ ; Jing LI ¹
Author Information

1. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Publication Type:Review
Keywords: S protein; SARS-CoV-2; angiotensin-converting enzyme 2; host; nonstructural protein
MeSH: Betacoronavirus/physiology*; COVID-19; Coronavirus Infections/virology*; Humans; Pandemics; Pneumonia, Viral/virology*; SARS-CoV-2; Virus Replication
From: Chinese Journal of Biotechnology 2020;36(10):1961-1969
CountryChina
Language:Chinese
Abstract: Coronaviruses are a type of positive-sense single-stranded RNA virus with envelope and widely exist in nature to cause respiratory infectious diseases. The novel coronavirus is a new outbreak virus that is susceptible to all people. Up to now, the disease has been widely spread in the world and poses a great threat to public health. In this review, the genomic features, key proteins, host infection and replication of coronaviruses and novel coronaviruses are reviewed in order to provide theoretical basis for the study of the pathogenic mechanism of virus infection on host cells and to provide basic support for the development of specific antiviral drugs.