Advances in molecular mechanisms of bone invasion by oral cancer.

Author: Wei LIU ¹ ; Chun-Jie LI ¹ ; Long-Jiang LI ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Publication Type:Review
Keywords: bone invasion; molecular mechanism; oral cancer; osteoclast
MeSH: Bone Resorption; Bone and Bones; Humans; Mouth Neoplasms; Osteoclasts; Osteoprotegerin; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B
From: West China Journal of Stomatology 2021;39(2):221-226
CountryChina
Language:Chinese
Abstract: Bone invasion by oral cancer is a common clinical problem, which affects the choice of treatment and predicts a poor prognosis. Unfortunately, the molecular mechanism of this phenomenon has not been fully elucidated. Current studies have revealed that oral cancer cells modulate the formation and function of osteoclasts through the expression of a series of signal molecules. Many signal pathways are involved in this process, of which receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB/osteoprotegerin signaling pathway attracted much attention. In this review, we introduce recent progress in molecular mechanisms of bone invasion by oral cancer.