Roles of autophagy onself-renewal and differentiation of mesenchymal stem cells.

Xin-chen Liu; Jin-jin LU; Yu-meng Chen; Ying Qiu; Meng-dan Zheng; Zi-lin Wang; Xiang-wei LI

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Roles of autophagy onself-renewal and differentiation of mesenchymal stem cells.

Author: Xin-Chen LIU ^{1
,

2} ; Jin-Jin LU ^{3
,

4} ; Yu-Meng CHEN ^{3
,

5} ; Ying QIU ^{1
,

2} ; Meng-Dan ZHENG ^{3
,

5} ; Zi-Lin WANG ^{3
,

5} ; Xiang-Wei LI ⁶
Author Information

1. Dept. of Endodontics, Jilin University Hospital of Stomatology, Changchun 130021, China
2. Jilin Province Key Laboratory of Dental Development and Jaw Remodeling and Regeneration, Changchun 130021, China.
3. Jilin Province Key Laboratory of Dental Development and Jaw Remodeling and Regeneration, Changchun 130021, China
4. Dept. of Pediatric Dentistry, Jilin University Hospital of Stomatology, Changchun 130021, China.
5. Dept. of Pathology, Jilin University Hospital of Stomatology, Changchun 130021, China.
6. Dept. of Endodontics, Jilin University Hospital of Stomatology, Changchun 130021, China.
Publication Type:Journal Article
Keywords: autophagy; differentiation; mesenchymal stem cell; self-renewal
MeSH: Autophagy; Cell Differentiation; Homeostasis; Mesenchymal Stem Cells
From: West China Journal of Stomatology 2020;38(6):704-707
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSCs), which have the potential of self-replication and differentiation, are a very valuable cell source for stem cell-based medical therapy. Their application has opened up a new way for disease research. Although MSCs can maintain cell stemness through self-renewal, with the prolongation of cell passage and culture time, the stemness of MSCs gradually decays, and the cell aging and differentiation potential decreases gradually. Autophagy is a highly conserved cytological process that degrades the modified, excess, and deleterious cytoplasmic components in autophagosomes, which are then degraded by fusion with lysosomes. As the main intracellular degradation and recycling pathway, autophagy plays an active role in maintaining cell homeostasis, self-renewal and pluripotency. In this paper, the role of autophagy in self-renewal and maintenance of multidirectional differentiation potential of MSCs was reviewed, which laid a theoretical foundation and practical basis for the research and application of MSCs.