Research progress in the osteogenetic mechanism of strontium.

Author: Ning-Ying ZHONG ^{1
,

2} ; Li-Ping WANG ³
Author Information

1. Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatological Hospital of Guangzhou Medical University, Guangzhou 510140, China
2. Stomatology Center, Shunde Hospital, Southern Medical University The First People's Hospital of Shunde, Foshan 528308, China.
3. Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatological Hospital of Guangzhou Medical University, Guangzhou 510140, China.
Publication Type:Journal Article
Keywords: bone metabolism; mechanism of action; strontium
MeSH: Bone Resorption; Humans; Osteoblasts; Osteoclasts; Osteogenesis; Strontium
From: West China Journal of Stomatology 2020;38(6):697-703
CountryChina
Language:Chinese
Abstract: Strontium (Sr) is an essential trace element and widely exists in nature. It plays an important role in the in vivo regulation of bone metabolism. Sr locates below Fe in the periodic table, and its chemical structure and polarity are similar to those of Ca. It can induce bone mesenchymal stem cells to differentiate into osteoblasts by inhibiting the activity of osteoclasts and reducing bone resorption. It promotes bone formation through a series of related pathways. The mechanism of Sr regulation of bone metabolism has been extensively researched in recent years. The current study aims to investigate the mechanism of Sr and provide a theoretical basis for its clinical application.