A Meta-analysis of the effect of non-surgical periodontal therapy on inflammatory factors in patients with chronic kidney disease and periodontitis.

Jing Lai; Yuan-liang Bai; Yin Bai; Jie Mei; Zhi-wei Zhang; Wen-jing Tang; Jiao Huang

Return

A Meta-analysis of the effect of non-surgical periodontal therapy on inflammatory factors in patients with chronic kidney disease and periodontitis.

Author: Jing LAI ^{1
,

2} ; Yuan-Liang BAI ^{1
,

2} ; Yin BAI ^{1
,

2} ; Jie MEI ^{1
,

2} ; Zhi-Wei ZHANG ^{1
,

3} ; Wen-Jing TANG ^{3
,

4} ; Jiao HUANG ^{1
,

2}
Author Information

1. Dept. of Periodontics, Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing 400015, China
2. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 400015, China.
3. Chongqing Medical University, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400015, China.
4. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 400015, China
Publication Type:Meta-Analysis
Keywords: C-reactive protein; chronic kidney disease; interleukin-6; periodontal therapy; periodontitis; tumor necrosis factor-α
MeSH: C-Reactive Protein; Chronic Periodontitis; Humans; Interleukin-6; Renal Insufficiency, Chronic/therapy*; Tumor Necrosis Factor-alpha
From: West China Journal of Stomatology 2020;38(6):672-680
CountryChina
Language:Chinese
Abstract: OBJECTIVE:A study was conducted to systematically evaluate the clinical efficacy of inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy.
METHODS:We searched the databases of CNKI, Wanfang, CBM, PubMed, Embase, and Cochrane Library from inception to December 2019. Two reviewers independently collected all literature related to inflammatory factors in patients with chronic kidney disease and periodontitis after non-surgical periodontal therapy. These factors include C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The literature was screened according to the inclusion and exclusion criteria. The quality of the studies was strictly evaluated, and the data were extracted. The literature of randomized controlled trials in accordance with the standards was Meta-analyzed with Revman 5.3 software.
RESULTS:Six randomized controlled trials were included. Compared with the control groups, the results of meta-analysis showed that non-surgical periodontal therapy significantly reduced the levels of CRP [MD=-0.58, 95%CI (-1.13, -0.02), P=0.04] and IL-6 [MD=-2.76, 95%CI (-5.15, -0.37), P=0.02] in these patients but not that of TNF-α [MD=-3.87, 95%CI (-8.79, 1.05), P=0.12].
CONCLUSIONS:Simultaneous regular renal treatment and non-surgical periodontal therapy can help relieve the periodontal damage on patients with chronic kidney disease and periodontitis. Moreover, it can improve the status of some inflammatory factors. This finding is conducive to the control and treatment of chronic kidney disease and periodontitis and needs to be a focus of research and in clinical operation.