Polymorphism of P66 in

Author: Qin HAO ¹ ; Hui Xin LIU ² ; Xue Xia HOU ¹ ; Lin ZHANG ¹ ; Xiao Na YANG ¹ ; Kang Lin WAN ¹
Author Information

1. State Key Laboratory of Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. The people's hospital of Liaocheng, Liaocheng 252400, Shandong, China.
Publication Type:Journal Article
Keywords: B-cell epitope; Borrelia burgdoferi; P66; Polymorphism
MeSH: Bacterial Proteins/genetics*; Borrelia burgdorferi/genetics*; China; Cluster Analysis; Epitopes, B-Lymphocyte/genetics*; Genetic Markers; Genotype; Humans; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Porins/genetics*
From: Biomedical and Environmental Sciences 2021;34(5):364-371
CountryChina
Language:English
Abstract: Objective:To study the polymorphism in P66 and its human B-cell epitopes of
Methods:Polymerase chain reaction (PCR) and sequencing were used to obtain the P66 sequences of 59 Chinese
Results:Results showed that genetic and amino acid diversity presented in the 66 kD protein of all 59 Chinese strains, especially in
Conclusion:In P66 of 59 Chinese strains, polymorphisms were widely distributed. More importantly, the P66 amino acid sequences of