Reciprocal Regulation between Fur and Two RyhB Homologs in

Author: Bin NI ^{1
,

2} ; Hai Sheng WU ² ; You Quan XIN ² ; Qing Wen ZHANG ² ; Yi Quan ZHANG ³
Author Information

1. School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, China
2. Qinghai Institute for Endemic Disease Prevention and Control, Xining 811602, Qinghai, China.
3. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Journal Article
Keywords: Biofilm; Fur; RyhB; Yersinia pestis
MeSH: Bacterial Proteins/metabolism*; Biofilms; Gene Expression Regulation, Bacterial/physiology*; Yersinia pestis/physiology*
From: Biomedical and Environmental Sciences 2021;34(4):299-308
CountryChina
Language:English
Abstract: Objective:To investigate reciprocal regulation between Fur and two RyhB homologs in
Methods:Regulatory relationships were assessed by a combination of colony morphology assay, primer extension, electrophoretic mobility shift assay and DNase I footprinting.
Results:Fur bound to the promoter-proximal DNA regions of
Conclusion:Fur and the two RyhB homologs exert negative reciprocal regulation, and RyhB homologs have a positive regulatory effect on biofilm formation in