Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood, Placental Size, and Risk for Fetal Growth Restriction: A Nested Case-control Study.

Yu Ting Jin; Xiao Kai Deng; Ying Ya Zhao; Jia Lin LI; Qi Song; Yun Hui Zhang; Qing Yang; Shang Qin Chen

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Concentrations of Polybrominated Diphenyl Ethers in Maternal Blood, Placental Size, and Risk for Fetal Growth Restriction: A Nested Case-control Study.

Author: Yu Ting JIN ^{1
,

2} ; Xiao Kai DENG ³ ; Ying Ya ZHAO ⁴ ; Jia Lin LI ⁴ ; Qi SONG ⁴ ; Yun Hui ZHANG ⁴ ; Qing YANG ⁵ ; Shang Qin CHEN ³
Author Information

1. Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China
2. Department of Pediatrics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang, China.
3. Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
4. Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
5. The Maternal and Child Healthcare Institute of Songjiang District, Shanghai 201600, China.
Publication Type:Journal Article
Keywords: Birth outcome; Fetal growth restriction; Maternal serum; Polybrominated diphenyl ethers
MeSH: Case-Control Studies; China/epidemiology*; Female; Fetal Growth Retardation/epidemiology*; Halogenated Diphenyl Ethers/blood*; Humans; Incidence; Infant, Newborn; Placenta/physiology*; Pregnancy; Risk Factors
From: Biomedical and Environmental Sciences 2020;33(11):821-828
CountryChina
Language:English
Abstract: Objective:To explore the effects of prenatal exposure to polybrominated diphenyl ethers (PBDEs) on placental size and birth outcomes.
Methods:Based on the perspective Wenzhou Birth Cohort, this nested case-control study included 101 fetal growth restriction (FGR) and 101 healthy newborns. Maternal serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass spectrometry. The basic information of mother-newborn pairs was collected from questionnaires, whereas the placental size and birth outcomes of newborns were obtained from hospital records.
Results:A total of 19 brominated diphenyle ether (BDE) congeners were detected in maternal serum samples. Higher concentrations of BDE-207, -208, -209, and ∑
Conclusion:A negative association was found between PBDE levels in maternal serum and placental size and birth outcomes. Prenatal PBDE exposure may be associated with elevated risk of the incidence of FGR birth.