Mitochondrial Oxidative Stress Enhances Vasoconstriction by Altering Calcium Homeostasis in Cerebrovascular Smooth Muscle Cells under Simulated Microgravity.
- Author:
Zi Fan LIU
1
;
Hai Ming WANG
1
;
Min JIANG
1
;
Lin WANG
1
;
Le Jian LIN
2
;
Yun Zhang ZHAO
1
;
Jun Jie SHAO
3
;
Jing Jing ZHOU
1
;
Man Jiang XIE
4
;
Xin LI
5
;
Ran ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Calcium homeostasis; Microgravity; Mitochondrial oxidative stress; Vasoconstriction
- MeSH: Animals; Calcium/metabolism*; Cerebral Arteries; Homeostasis; Male; Mitochondria/physiology*; Myocytes, Smooth Muscle/physiology*; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vasoconstriction/physiology*; Weightlessness Simulation
- From: Biomedical and Environmental Sciences 2021;34(3):203-212
- CountryChina
- Language:English
-
Abstract:
Objective:Exposure to microgravity results in postflight cardiovascular deconditioning in astronauts. Vascular oxidative stress injury and mitochondrial dysfunction have been reported during this process. To elucidate the mechanism for this condition, we investigated whether mitochondrial oxidative stress regulates calcium homeostasis and vasoconstriction in hindlimb unweighted (HU) rat cerebral arteries.
Methods:Three-week HU was used to simulate microgravity in rats. The contractile responses to vasoconstrictors, mitochondrial fission/fusion, Ca
Results:An increase of cytoplasmic Ca
Conclusion:The present results suggest that mitochondrial oxidative stress enhances cerebral vasoconstriction by regulating calcium homeostasis during simulated microgravity.
