Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium.

Author: Jelena KULAS ¹ ; Dina TUCOVIC ¹ ; Milica ZELJKOVIC ¹ ; Dusanka POPOVIC ¹ ; Aleksandra POPOV ALEKSANDROV ¹ ; Milena KATARANOVSKI ¹ ; Ivana MIRKOV ¹
Author Information

1. Immunotoxicology Group, Department of Ecology, Institute for Biological Research 'Siniša Stanković'- National Institute of Republic of Serbia, University of Belgrade, 142 Bulevar despota Stefana, Belgrade 11000, Serbia.
Publication Type:Journal Article
Keywords: Aryl hydrocarbon receptor; Cadmium; Cytokine (IL-6, TNF, IL-1β) response; Lung leukocytes
MeSH: Animals; Basic Helix-Loop-Helix Transcription Factors/immunology*; Cadmium/toxicity*; Cytochrome P-450 CYP1A1/immunology*; Cytochrome P-450 CYP1B1/immunology*; Cytokines/immunology*; Environmental Pollutants/toxicity*; Male; Rats; Receptors, Aryl Hydrocarbon/immunology*
From: Biomedical and Environmental Sciences 2021;34(3):192-202
CountryChina
Language:English
Abstract: Objective:To investigate involvement of the aryl hydrocarbon receptor (AhR) in the immunomodulatory effects of cadmium (Cd).
Methods:The effect of Cd on AhR activation (
Results:Cd increased
Conclusion:AhR signaling is involved in the lung leukocyte proinflammatory cytokine response to Cd. The relevance of the AhR to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.