Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing

Xiao Yan Gai; Hong Bin Chi; Lin Zeng; Wen Li Cao; Li Xue Chen; Chen Zhang; Ming LU; Lan Ding Ning; Chun Chang; Wei Xia Zhang; Ping Liu; Rong LI; Yong Chang Sun; Jie Qiao

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Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing

Author: Xiao Yan GAI ¹ ; Hong Bin CHI ^{2
,

3} ; Lin ZENG ⁴ ; Wen Li CAO ⁵ ; Li Xue CHEN ^{2
,

3} ; Chen ZHANG ⁶ ; Ming LU ¹ ; Lan Ding NING ¹ ; Chun CHANG ¹ ; Wei Xia ZHANG ¹ ; Ping LIU ^{2
,

3} ; Rong LI ^{2
,

3} ; Yong Chang SUN ¹ ; Jie QIAO ^{2
,

3}
Author Information

1. Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
2. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
3. National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China.
4. Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.
5. Tuberculosis Department, Beijing Geriatric Hospital, Beijing 102699, China.
6. Information Center, Peking University Third Hospital, Beijing 100191, China.
Publication Type:Journal Article
Keywords: Embryo transfer; In vitro fertilization; Infertility; Pregnancy outcome; Tuberculosis
MeSH: Abortion, Spontaneous/epidemiology*; Adult; China/epidemiology*; Embryo Transfer/statistics & numerical data*; Female; Fertilization in Vitro/statistics & numerical data*; Humans; Infertility, Female/etiology*; Live Birth/epidemiology*; Middle Aged; Pregnancy; Pregnancy Complications, Infectious/epidemiology*; Pregnancy Outcome/epidemiology*; Radiography, Thoracic; Retrospective Studies; Tuberculosis, Pulmonary/epidemiology*; Young Adult
From: Biomedical and Environmental Sciences 2021;34(2):130-138
CountryChina
Language:English
Abstract: Objective:Prior pulmonary tuberculosis (PTB) on chest X-ray (CXR) was commonly found in infertile patients receiving examinations before
Method:We conducted a retrospective cohort study of 14,254 infertile patients who had received IVF-ET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. Live birth, clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB groups.
Results:The untreated PTB group had significantly lower clinical pregnancy (31.7%
Conclusions:Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population.