Human Serum-derived Extracellular Vesicles Protect A549 from PM

Qiu Lian Zhou; Yu Zheng Bai; Juan Gao; Yi Duan; Yi Cheng Lyu; Long Fei Guan; Kenneth Elkin; Yu Ling Xie; Zheng Jiao; Hong Yun Wang

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Human Serum-derived Extracellular Vesicles Protect A549 from PM

Author: Qiu Lian ZHOU ^{1
,

2} ; Yu Zheng BAI ³ ; Juan GAO ⁴ ; Yi DUAN ³ ; Yi Cheng LYU ³ ; Long Fei GUAN ⁵ ; Kenneth ELKIN ⁶ ; Yu Ling XIE ³ ; Zheng JIAO ² ; Hong Yun WANG ³
Author Information

1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China
2. Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
3. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
4. School of Medicine, Shanghai University, Shanghai 200444, China.
5. China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China.
6. Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Publication Type:Journal Article
Keywords: AKT; Cell apoptosis; Extracellular vesicles; PM2.5; Therapy
MeSH: A549 Cells; Air Pollutants/toxicity*; Apoptosis/drug effects*; Cell Survival/drug effects*; Extracellular Vesicles; Humans; Male; Middle Aged; Particulate Matter/toxicity*; Protective Agents/pharmacology*; Proto-Oncogene Proteins c-akt/metabolism*; Serum
From: Biomedical and Environmental Sciences 2021;34(1):40-49
CountryChina
Language:English
Abstract: Objective:Epidemiological studies reveal that exposure to fine particulate matter (aerodynamic diameter ≤ 2.5 μm, PM
Methods:EVs were isolated from the serum of healthy subjects, quantified
Results:PM
Conclusions:EVs treatment promotes cell survival and attenuates PM