Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.

Yuan Yue Zhu; Rui Zhi Zheng; Gui Xia Wang; Li Chen; Li Xin Shi; Qing SU; Min XU; Yu XU; Yu Hong Chen; Xue Feng YU; Li Yan; Tian Ge Wang; Zhi Yun Zhao; Gui Jun Qin; Qin Wan; Gang Chen; Zheng Nan Gao; Fei Xia Shen; Zuo Jie Luo; Ying Fen Qin; Ya Nan Huo; Qiang LI; Zhen YE; Yin Fei Zhang; Chao Liu; You Min Wang; Sheng Li WU; Tao Yang; Hua Cong Deng; Jia Jun Zhao; Lu Lu Chen; Yi Ming MU; Xu Lei Tang; Ru Ying HU; Wei Qing Wang; Guang Ning; Mian LI; Jie Li LU; Yu Fang BI

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Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.

Author: Yuan Yue ZHU ^{1
,

2} ; Rui Zhi ZHENG ^{1
,

2} ; Gui Xia WANG ³ ; Li CHEN ⁴ ; Li Xin SHI ⁵ ; Qing SU ⁶ ; Min XU ^{1
,

2} ; Yu XU ^{1
,

2} ; Yu Hong CHEN ^{1
,

2} ; Xue Feng YU ⁷ ; Li YAN ⁸ ; Tian Ge WANG ^{1
,

2} ; Zhi Yun ZHAO ^{1
,

2} ; Gui Jun QIN ⁹ ; Qin WAN ¹⁰ ; Gang CHEN ¹¹ ; Zheng Nan GAO ¹² ; Fei Xia SHEN ¹³ ; Zuo Jie LUO ¹⁴ ; Ying Fen QIN ¹⁴ ; Ya Nan HUO ¹⁵ ; Qiang LI ¹⁶ ; Zhen YE ¹⁷ ; Yin Fei ZHANG ¹⁸ ; Chao LIU ¹⁹ ; You Min WANG ²⁰ ; Sheng Li WU ²¹ ; Tao YANG ²² ; Hua Cong DENG ²³ ; Jia Jun ZHAO ²⁴ ; Lu Lu CHEN ²⁵ ; Yi Ming MU ²⁶ ; Xu Lei TANG ²⁷ ; Ru Ying HU ¹⁷ ; Wei Qing WANG ^{1
,

2} ; Guang NING ^{1
,

2} ; Mian LI ^{1
,

2} ; Jie Li LU ^{1
,

2} ; Yu Fang BI ^{1
,

2}
Author Information

1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
3. The First Hospital of Jilin University, Changchun 130021, Jinlin, China.
4. Qilu Hospital of Shandong University, Jinan 250012, Shandong, China.
5. Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China.
6. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.
7. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
8. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China.
9. The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
10. The Affiliated Hospital of Southwest Medical University, Luzhou 646099, Sichuan, China.
11. Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China.
12. Dalian Municipal Central Hospital, Dalian 116003, Liaoning, China.
13. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China.
14. The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
15. Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi, China.
16. The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China.
17. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.
18. Central Hospital of Shanghai Jiading District, Shanghai 201800, China.
19. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, Jiangsu, China.
20. The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China.
21. Karamay Municipal People's Hospital, Karamay 830054, Xinjiang, China.
22. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.
23. The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
24. Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, China.
25. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
26. Chinese People's Liberation Army General Hospital, Beijing 100853, China.
27. The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China.
Publication Type:Journal Article
Keywords: Cross-sectional study; Glycemic index; Glycemic status; Serum uric acid
MeSH: Aged; Asian Continental Ancestry Group; Blood Glucose/analysis*; China/epidemiology*; Cohort Studies; Diabetes Mellitus/blood*; Female; Glucose Tolerance Test; Glycated Hemoglobin A/analysis*; Glycemic Index; Humans; Male; Middle Aged; Uric Acid/blood*
From: Biomedical and Environmental Sciences 2021;34(1):9-18
CountryChina
Language:English
Abstract: Objective:The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.
Methods:The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.
Results:A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).
Conclusion:An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.