Assessment on the Effects of Hepatitis B Prevention and Control Measures in Western China: A Comparison of Three Population-based Serosurveys.

Hui Chen; Nan Liu; Zhao Hua JI; Zhong Shu PU; Zhi Wen Guo; Jie Gao; Zhong Jun Shao; Yi Wen Liu; Yong Ping Yan

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Assessment on the Effects of Hepatitis B Prevention and Control Measures in Western China: A Comparison of Three Population-based Serosurveys.

Author: Hui CHEN ¹ ; Nan LIU ¹ ; Zhao Hua JI ¹ ; Zhong Shu PU ¹ ; Zhi Wen GUO ² ; Jie GAO ¹ ; Zhong Jun SHAO ¹ ; Yi Wen LIU ² ; Yong Ping YAN ¹
Author Information

1. Department of Epidemiology, School of Public Health, Air Force Medical University, Xi'an 710032, Shaanxi, China.
2. Wuwei municipal Center for Disease Control and Prevention, Wuwei 733000, Gansu, China.
Publication Type:Journal Article
Keywords: Hepatitis B; Prevention and control measures; Serosurvey; Western China
MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; China/epidemiology*; Communicable Disease Control/statistics & numerical data*; Cross-Sectional Studies; Female; Hepatitis B/prevention & control*; Hepatitis B virus/isolation & purification*; Humans; Infant; Infant, Newborn; Male; Middle Aged; Prevalence; Seroepidemiologic Studies; Young Adult
From: Biomedical and Environmental Sciences 2020;33(10):735-744
CountryChina
Language:English
Abstract: Objective:Despite the remarkable progress in efforts to control disease spread, the nationwide elimination of hepatitis B in China is still hindered by the persistently high rate of hepatitis B virus (HBV) infection in Western China. This study aimed to evaluate the strategy of hepatitis B prevention and control in Western China and identify potential areas and strategies for improvement.
Methods:Susceptible population vaccination, health education, professional training of doctors, and other prevention and control measures have been implemented in Wuwei city since 2010. Data were obtained from three representative cross-sectional serosurveys conducted in 2010, 2013, and 2015. The serum samples were subjected to enzyme-linked immunosorbent assays to detect the following seromarkers: HBV surface antigen (HBsAg), antibody against hepatitis B surface antigen (anti-HBs), and antibody against hepatitis B core antigen (anti-HBc). Estimates of variance were determined using Taylor series linearization methods.
Results:The three serosurveys revealed decreases in the prevalence of HBsAg (7.19% in 2010
Conclusion:Although vaccine-based prevention and control measures reduced the rate of HBV infection in Wuwei City over time, the hepatitis B infection rate in children younger than 10 years was still higher than the national average level. Therefore, the prevention and control of mother-to-child transmission and the management of the infected should be the focus of future prevention and control work.