Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention.
- Author:
Bo-Wen LI
1
;
Li-Li FENG
1
;
Zhen-Jun TIAN
2
Author Information
1. Department of Sports and Cardiovascular Health, Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi'an 710119, China.
2. Department of Sports and Cardiovascular Health, Institute of Sports Biology, College of Physical Education, Shaanxi Normal University, Xi'an 710119, China. tianzhj@snnu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Exercise Therapy;
Humans;
Insulin-Like Growth Factor I;
Liver;
Metabolic Diseases/therapy*;
Muscle, Skeletal
- From:
Acta Physiologica Sinica
2021;73(2):342-352
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.
