Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease.
- Author:
Xiao-Rui WANG
1
,
2
;
Song-Xin ZHU
1
,
2
;
Xiao-Ming WEN
1
,
2
;
Jun-Xia XIE
1
,
2
;
Ning SONG
1
,
3
Author Information
1. Department of Physiology and Pathophysiology, School of Basic Medicine
2. Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China.
3. Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China. ningsong@qdu.edu.cn.
- Publication Type:Review
- MeSH:
Dopamine;
Dopaminergic Neurons;
Humans;
Parkinson Disease/etiology*;
Substantia Nigra;
alpha-Synuclein/metabolism*
- From:
Acta Physiologica Sinica
2021;73(1):89-102
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). Genetic vulnerability, aging, environmental insults are believed to contribute to the pathogenesis of PD. However, the cellular and molecular mechanism of dopaminergic neurons degeneration remains incompletely understood. Dopamine (DA) metabolism is a cardinal physiological process in dopaminergic neurons, which is closely related to the loss of dopaminergic neurons in the SN. DA metabolism takes part in several pathological processes of PD neurodegeneration, such as iron metabolism disturbance, α-synuclein mis-folding, endoplasmic reticulum stress, protein degradation dysfunction, neuroinflammatory response, etc. In this review, we will describe altered DA metabolism and its contributions to PD pathogenesis.
