Roles of smooth muscle 22α in vascular homeostasis and vascular remodeling.
- Author:
Ning ZHANG
1
;
Yong-Qing DOU
1
;
Mei HAN
2
Author Information
1. College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China.
2. College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China. hanmei@hebmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Cell Proliferation;
Cells, Cultured;
Homeostasis;
Humans;
Muscle Proteins;
Muscle, Smooth, Vascular;
Myocytes, Smooth Muscle;
Phenotype;
Vascular Remodeling
- From:
Acta Physiologica Sinica
2021;73(1):82-88
- CountryChina
- Language:Chinese
-
Abstract:
The research on the molecular mechanism of vascular injury has been a hot topic in recent years since the mechanism can be targeted for the treatment of vascular injury diseases. A large number of studies have found that vascular injury, repair and pathological remodeling are closely related to phenotype switching, abnormal proliferation and migration, and apoptosis of vascular smooth muscle cells (VSMCs). Smooth muscle 22α (SM22α) is a shape change and transformation sensitive F-actin-binding protein. SM22α decorates the contractile filament bundles within cultured VSMCs exhibiting differentiated phenotypes. In addition, SM22α is involved in regulation of cell signaling pathways related to vascular homeostasis and vascular remodeling. Here, we reviewed the recent research progress of SM22α in vascular homeostasis and remodeling.
