17β-estradiol inhibits interleukin-1β-induced rat nucleus pulposus cell apoptosis through the PI3K/Akt/mTOR signal pathway.
- Author:
Hong-Tao GUO
1
;
Er-Fei GUO
1
;
Jian-Jie XU
1
;
Bin ZHANG
1
;
Yan-Bing GAO
1
;
Jian-Zhong WU
2
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Estradiol/pharmacology*; Glycogen Synthase Kinase 3 beta; Interleukin-1beta; Nucleus Pulposus/metabolism*; Phosphatidylinositol 3-Kinases/metabolism*; Proto-Oncogene Proteins c-akt/metabolism*; Rats; Signal Transduction; TOR Serine-Threonine Kinases
- From: Acta Physiologica Sinica 2021;73(1):62-68
- CountryChina
- Language:Chinese
- Abstract: The apoptosis of nucleus pulposus cells (NPCs) is the main cellular process of intervertebral disc degeneration (IVDD). Our previous studies showed that 17β-estradiol (E
