Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion.
- Author:
Mei-Ling TAN
1
;
Chun-Jiao LONG
1
;
Wang JIANG
1
;
Jin-Mei WANG
1
;
Jiao PI
1
;
Xiao-Qun QIN
1
;
Yang XIANG
2
Author Information
1. Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410078, China.
2. Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410078, China. xiangyang@csu.edu.cn.
- Publication Type:Review
- MeSH:
Cell Adhesion;
Cell Adhesion Molecules;
Epithelial Cells;
Epithelial-Mesenchymal Transition;
Respiratory System
- From:
Acta Physiologica Sinica
2020;72(5):605-616
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.
