Research progress of non-coding RNA in regulating the function of T cells in asthma.
- Author:
Zhen-Li HUANG
1
;
Wei-Ning XIONG
2
Author Information
1. Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2. Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. xiongdoctor@qq.com.
- Publication Type:Review
- MeSH:
Asthma/genetics*;
Humans;
MicroRNAs/genetics*;
RNA, Long Noncoding/genetics*;
RNA, Untranslated/genetics*;
T-Lymphocytes
- From:
Acta Physiologica Sinica
2020;72(5):586-596
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma (i.e. asthma) is a chronic inflammatory disease characterized by airway inflammatory response, hyperresponsiveness and airway remodeling, in which T cells play a vital role, especially T helper cells (Th cells). Non-coding RNAs (ncRNAs) are the RNAs that do not encode proteins, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are widely found in eukaryotic genomes and participate in the regulation of various biological processes. Previous studies have shown that ncRNAs play an important role in the activation and transformation of T cells and other biological processes in asthma. The specific molecular mechanism and clinical application are worth in-depth discussion. This article reviewed the research progress in regulation of miRNAs, lncRNAs and circRNAs on T cells in asthma in recent years.
