Ferroptosis in respiratory diseases.
- Author:
Hai-Xia CHEN
1
;
Yan-Ping WU
1
;
Wen LI
1
;
Hua-Hao SHEN
1
;
Zhi-Hua CHEN
2
Author Information
1. Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
2. Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. zhihuachen@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Cell Death;
Ferroptosis;
Humans;
Iron;
Reactive Oxygen Species;
Respiration Disorders
- From:
Acta Physiologica Sinica
2020;72(5):575-585
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.
