Pandemic of the aging society - sporadic cerebral small vessel disease.

Alexander Yuk Lun Lau; Bonaventure Yiu Ming IP; Ho KO; Bonnie Yin Ka Lam; Lin Shi; Karen Ka Yan MA; Lisa Wing Chi AU; Yannie Oi Yan Soo; Thomas Wai Hong Leung; Adrian Wong; Vincent Chung Tong Mok

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Pandemic of the aging society - sporadic cerebral small vessel disease.

Author: Alexander Yuk Lun LAU ¹ ; Bonaventure Yiu Ming IP ¹ ; Ho KO ¹ ; Bonnie Yin Ka LAM ¹ ; Lin SHI ² ; Karen Ka Yan MA ¹ ; Lisa Wing Chi AU ¹ ; Yannie Oi Yan SOO ¹ ; Thomas Wai Hong LEUNG ¹ ; Adrian WONG ¹ ; Vincent Chung Tong MOK ¹
Author Information

1. Division of Neurology, Department of Medicine and Therapeutics, The Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
2. Margaret Cheung K. L. Cheung Research Centre for Management of Parkinsonism, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Publication Type:Review
MeSH: Aged; Aging; Brain/diagnostic imaging*; Cerebral Small Vessel Diseases/epidemiology*; Humans; Magnetic Resonance Imaging; Pandemics
From: Chinese Medical Journal 2021;134(2):143-150
CountryChina
Language:English
Abstract: Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.