An update on the role of long non-coding RNAs in psoriasis.
10.1097/CM9.0000000000001243
- Author:
Jian-Kun SONG
1
;
Shuang-Yi YIN
2
;
Wei LI
2
;
Xiao-Dong LI
3
;
Yue LUO
1
;
Ying LUO
4
;
Meng XING
1
;
Bin LI
1
;
Le KUAI
1
Author Information
1. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
2. Center for Translational Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan 475001, China.
3. Department of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan 475001, China.
4. Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Review
- MeSH:
Humans;
Psoriasis/genetics*;
RNA, Long Noncoding/genetics*
- From:
Chinese Medical Journal
2020;134(4):379-389
- CountryChina
- Language:English
-
Abstract:
Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational levels; however, the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored. This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendritic cells.
