Heterogeneity of HIV-1 latent reservoirs.
10.1097/CM9.0000000000001085
- Author:
Jia-Cong ZHAO
1
;
Kai DENG
1
Author Information
1. Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
- Publication Type:Journal Article
- MeSH:
CD4-Positive T-Lymphocytes;
HIV Infections/drug therapy*;
HIV-1;
Humans;
Viral Load;
Virus Latency;
Virus Replication
- From:
Chinese Medical Journal
2020;133(23):2867-2873
- CountryChina
- Language:English
-
Abstract:
Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses. In order to reduce or eliminate the HIV-1 latent reservoir, characteristics of the latently infected cells need to be intensively studied, and a comprehensive understanding of the heterogenous nature of the latent reservoir will be critical to develop novel therapeutic strategies. Here, we discuss the different cell types and mechanisms contributing to the complexity and heterogeneity of HIV-1 latent reservoirs, and summarize the key challenges to the development of cure strategies for acquired immunodeficiency syndrome (AIDS).
