Asymptomatic cryptococcal antigenemia in HIV-infected patients: a review of recent studies.
10.1097/CM9.0000000000001134
- Author:
Xiao-Lei XU
1
;
Ting ZHAO
2
;
Vijay HARYPURSAT
1
;
Yan-Qiu LU
1
;
Yan LI
3
;
Yao-Kai CHEN
1
Author Information
1. Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing 400036, China.
2. Division of Science and Education, Chongqing Public Health Medical Center, Chongqing 400036, China.
3. Public Health College, Zunyi Medical University, Zunyi, Guizhou 563000, China.
- Publication Type:Review
- MeSH:
AIDS-Related Opportunistic Infections;
CD4 Lymphocyte Count;
China;
Cryptococcosis/epidemiology*;
Cryptococcus;
HIV Infections/complications*;
Humans;
Meningitis, Cryptococcal
- From:
Chinese Medical Journal
2020;133(23):2859-2866
- CountryChina
- Language:English
-
Abstract:
The prevalence of asymptomatic cryptococcal antigenemia (ACA) in human immunodeficiency virus (HIV) infected individuals has been observed to be elevated. The prevalence of ACA ranges from 1.3% to 13%, with different rates of prevalence in various regions of the world. We reviewed studies conducted internationally, and also referred to two established expert consensus guideline documents published in China, and we have concluded that Chinese HIV-infected patients should undergo cryptococcal antigen screening when CD4 T-cell counts fall below 200 cells/μL and that the recommended treatment regimen for these patients follow current World Health Organization guidelines, although it is likely that this recommendation may change in the future. Early screening and optimized preemptive treatment for ACA is likely to help decrease the incidence of cryptococcosis, and is lifesaving. Further studies are warranted to explore issues related to the optimal management of ACA.
