Research progress and perspective in metabolism and metabolomics of psoriasis.
10.1097/CM9.0000000000001242
- VernacularTitle:Research progress and perspective in metabolism and metabolomics of psoriasis
- Author:
Ni LIAN
1
;
Li-Qing SHI
;
Zhi-Min HAO
;
Min CHEN
Author Information
1. Department of Dermatology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical Collage, Nanjing, Jiangsu 210042, China.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
Humans;
Metabolomics;
Phenotype;
Psoriasis
- From:
Chinese Medical Journal
2020;133(24):2976-2986
- CountryChina
- Language:English
-
Abstract:
Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.
