Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis.
10.1097/CM9.0000000000001240
- Author:
Jing-Yi MA
1
;
Shuai SHAO
;
Gang WANG
Author Information
1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
- Publication Type:Review
- MeSH:
Adaptive Immunity;
Humans;
Immunity, Innate;
Pore Forming Cytotoxic Proteins;
Psoriasis;
Skin Diseases;
beta-Defensins
- From:
Chinese Medical Journal
2020;133(24):2966-2975
- CountryChina
- Language:English
-
Abstract:
Antimicrobial peptides (AMPs) are small molecules produced by a myriad of cells and play important roles not only in protecting against infections and sustaining skin barrier homeostasis but also in contributing to immune dysregulation under pathological conditions. Recently, increasing evidence has indicated that AMPs, including cathelicidin (LL-37), human β-defensins, S100 proteins, lipocalin 2, and RNase 7, are highly expressed in psoriatic skin lesions. These peptides broadly regulate immunity by interacting with various immune cells and linking innate and adaptive immune responses during the progression of psoriasis. In this review, we summarize the recent findings regarding AMPs in the pathogenesis of psoriasis with a main focus on their immunomodulatory abilities.
