Liver Abscess in Advanced Hepatocellular Carcinoma after Sorafenib Treatment.
- Author:
Seung Kak SHIN
1
;
Young Kul JUNG
;
Hyun Hwa YOON
;
Oh Sang KWON
;
Yun Soo KIM
;
Duck Joo CHOI
;
Ju Hyun KIM
Author Information
- Publication Type:Case Reports
- Keywords: Sorafenib; Hepatocellular carcinoma; Liver abscess
- MeSH: Anti-Bacterial Agents/therapeutic use; Antineoplastic Agents/adverse effects/*therapeutic use; Carcinoma, Hepatocellular/*drug therapy/radiography; Clostridium/isolation & purification; Clostridium Infections/drug therapy/microbiology; Humans; Liver Abscess/etiology/*microbiology; Liver Neoplasms/*drug therapy/radiography; Male; Middle Aged; Niacinamide/adverse effects/*analogs & derivatives/therapeutic use; Phenylurea Compounds/adverse effects/*therapeutic use; Tomography, X-Ray Computed
- From:The Korean Journal of Gastroenterology 2014;63(1):47-50
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatocellular carcinoma (HCC) is a critical global health issue and the third most common cause of cancer-related deaths worldwide. The majority of patients who present HCC are already at an advanced stage and their tumors are unresectable. Sorafenib is a multi-kinase inhibitor of the vascular endothelial growth factor pathway and was recently introduced as a therapy for advanced HCC. Furthermore, studies have shown that oral sorafenib has beneficial effects on survival. However, many patients experience diverse side effects, and some of these are severe. Liver abscess development has not been previously documented to be associated with sorafenib administration in HCC. Here, we report the case of a HCC patient that developed a liver abscess while being treated with sorafenib.
