Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer.
10.1097/CM9.0000000000001141
- VernacularTitle:Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer
- Author:
Xiao-Lin SU
1
;
Jiang-Wei WANG
2
;
Hui CHE
3
;
Chang-Fu WANG
4
;
Hai JIANG
1
;
Xia LEI
1
;
Wan ZHAO
1
;
Hai-Xue KUANG
1
;
Qiu-Hong WANG
4
Author Information
1. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
2. Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46022, USA.
3. Department of Endocrinology, The Second affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China.
4. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
- Publication Type:Review
- MeSH:
Combined Modality Therapy;
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Lung Neoplasms/drug therapy*;
Medicine, Chinese Traditional;
Protein Kinase Inhibitors;
Quality of Life
- From:
Chinese Medical Journal
2020;133(24):2987-2997
- CountryChina
- Language:English
-
Abstract:
Lung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in vitro and in vivo. We summarized the recent 5 years of different research progress on clinical applications and antitumor mechanisms of TCM in the treatment of lung cancer. As a potent adjuvant therapy, TCM could enhance conventional treatments (chemotherapy, radiation therapy, and epidermal growth factor receptors [EGFRs] tyrosine kinase inhibitors [TKIs]) effects as well as provide synergistic effects, enhance chemotherapy drugs chemosensitivity, reverse drug resistance, reduce adverse reactions and toxicity, relieve patients' pain and improve quality of life (QOL). After treating with TCM, lung cancer cells will induce apoptosis and/or autophagy, suppress metastasis, impact immune reaction, and therapeutic effect of EGFR-TKIs. Therefore, TCM is a promisingly potent adjuvant therapy in the treatment of lung cancer and its multiple mechanisms are worthy of an in-depth study.
