Progress of antibiotic-loaded bone cement in joint arthroplasty.
10.1097/CM9.0000000000001093
- Author:
Yi-Ming XU
1
;
Hui-Ming PENG
;
Bin FENG
;
Xi-Sheng WENG
Author Information
1. Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents/therapeutic use*;
Arthroplasty, Replacement, Knee;
Bone Cements;
Humans;
Polymethyl Methacrylate;
Prosthesis-Related Infections/drug therapy*
- From:
Chinese Medical Journal
2020;133(20):2486-2494
- CountryChina
- Language:English
-
Abstract:
Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.
