PLA2R1 and HLA-DQA1 gene variations in idiopathic membranous nephropathy in South China.
10.47102/annals-acadmedsg.2020138
- Author:
Fan WANG
1
;
Ting-Ting WANG
;
Xiao-Wan LIANG
;
Jian-Da LU
;
Qiong-Hong XIE
;
Rui-Ying CHEN
;
Jun XUE
Author Information
1. Department of Nephropathy, Huashan Hospital, Fudan University, Shanghai, China.
- Publication Type:Journal Article
- From:Annals of the Academy of Medicine, Singapore
2021;50(1):33-41
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Associations of variations in PLA2R1 and HLA-DQA1 genes with susceptibility to idiopathic membranous nephropathy (IMN) have been well documented. Association with spontaneous remission, however, is poorly defined in the Chinese Han population.
METHODS:A Chinese cohort of 117 IMN patients and 138 healthy controls were recruited between July 2009 and November 2019. Case-control studies for single-nucleotide polymorphisms (SNPs) within HLA-DQA1 (rs2187668) and PLA2R1 (rs35771982, rs4664308, rs3749117, rs3749119) genes were performed. The contributions of these polymorphisms to predict susceptibility, titre of autoantibodies against the M-type phospholipase A2 receptor (anti-PLA2R1), glomerular PLA2R1 expression, and spontaneous remission were analysed.
RESULTS:We found that variations in PLA2R1 (SNPs rs35771982, rs4664308, rs3749117) were strongly associated with IMN susceptibility, while SNP (rs2187668) within HLA-DQA1 did not increase the risk of IMN. All SNPs in PLA2R1 and HLA-DQA1 were not statistically associated with anti-PLA2R1 titre, glomerular PLA2R1 expression and spontaneous remission after Bonferroni correction (
CONCLUSION:This study confirms that variations in PLA2R1 (SNPs rs35771982, rs4664308, rs3749117) are risk factors for IMN. We found excellent association of serum albumin level, anti-PLA2R1 titre and glomerular PLA2R1 positivity with non-spontaneous remission in IMN.
