Association of Cord Blood Thyroid-Stimulating Hormone Levels with Maternal, Delivery and Infant Factors.
10.47102/annals-acadmedsg.2020471
- Author:
Karen M L TAN
1
;
Anne H Y CHU
;
See Ling LOY
;
Victor Samuel RAJADURAI
;
Clement K M HO
;
Yap Seng CHONG
;
Neerja KARNANI
;
Yung Seng LEE
;
Fabian Kok Peng YAP
;
Shiao Yng CHAN
Author Information
1. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
- Publication Type:Journal Article
- From:Annals of the Academy of Medicine, Singapore
2020;49(12):937-947
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:This study examined maternal, delivery and infant factors associated with cord thyroid-stimulating hormone (TSH) concentrations in an Asian population.
METHODS:The Growing Up in Singapore Towards healthy Outcomes (GUSTO) study is a mother-offspring birth cohort from 2 major hospitals in Singapore. Cord serum TSH was measured using the Abbott ARCHITECT TSH Chemiluminescent Microparticle Immunoassay and the ADVIA Centaur TSH-3 Immunoassay. After excluding infants with a maternal history of thyroid disease, screening cord TSH results from 604 infants were available for multivariable regression analysis in relation to the factors of interest.
RESULTS:Babies born by vaginal delivery had significantly higher cord serum TSH concentrations than babies born by caesarean section. Cord serum TSH concentrations differed significantly by measurement method. There was no association of cord TSH concentrations with ethnicity, sex, birth weight, gestational age, maternal body mass index, gestational weight gain, gestational diabetes mellitus status and other maternal, delivery and infant factors studied.
CONCLUSION:Interpretation of cord serum TSH results may need to take into account mode of delivery and measurement method.
