Effect of acupuncture on intestinal flora and TLR4 in brain and intestinal tissues in rats with stress gastric ulcer.

Author: Jia-Yu ZHAO ¹ ; Tu-Nan WANG ¹ ; Liu-Jing WANG ¹ ; Xue TING ¹ ; Ying-Qi WU ¹ ; Zi-Xian ZHOU ¹ ; Yi-Chen YANG ¹ ; Yi-Xuan SHAO ¹ ; Hui-Fang MA ¹
Author Information

1. College of Acupuncture-Moxibustion and Tuina, Beijing University of CM, Beijing 100029, China.
Publication Type:Journal Article
Keywords: acupuncture; intestinal flora; stress gastric ulcer (SGU); toll-like receptor 4 (TLR4)
MeSH: Acupuncture Points; Acupuncture Therapy; Animals; Brain; Gastrointestinal Microbiome; Male; Rats; Rats, Sprague-Dawley; Stomach Ulcer/therapy*; Toll-Like Receptor 4/genetics*
From: Chinese Acupuncture & Moxibustion 2021;41(4):413-419
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To observe the effect of acupuncture at "Guanyuan" (CV 4) and "Xiajuxu" (ST 39) on intestinal flora and Toll-like receptors-4 (TLR4) in brain and intestinal tissue in rats with stress gastric ulcer (SGU), and to explore the possible mechanism of acupuncture for SGU.
METHODS:Thirty-one male SD rats were randomly divided into a blank group (
RESULTS:Compared with the blank group, the gastric mucosal damage index was significantly increased in the model group (
CONCLUSION:Acupuncture at "Guanyuan" (CV 4) and "Xiajuxu" (ST 39) could alleviate SGU in rats, and its mechanism may be related to increasing the diversity of intestinal flora, promoting the disorder of intestinal flora to normal, and reducing the overexpression of TLR4 in brain and intestinal tissues.