Effect of electroacupuncture on lung dysplasia in rats with intrauterine growth restriction induced by maternal food restriction.
10.13703/j.0255-2930.20200507-k0008
- Author:
Qiu-Jie MOU
1
;
Bo JI
1
;
Guo-Zhen ZHAO
2
;
Yi-Tian LIU
1
;
Jian DAI
1
;
Ya-Wen LU
1
;
Sakurai REIKO
3
;
Kumar Rehan VIRENDER
3
;
Ya-Na XIE
1
;
Qin ZHANG
1
;
Tian-Yu SHI
1
Author Information
1. College of Acupuncture-Moxibustion and Tuina, Beijing University of CM, Beijing 100029, China.
2. Beijing Hospital of TCM, Capital Medical University.
3. Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles 90502, USA.
- Publication Type:Journal Article
- Keywords:
electroacupuncture;
intrauterine growth restriction (IUGR);
lung development;
maternal food restriction;
peroxisome proliferator activated receptor γ(PPARγ)
- MeSH:
Acupuncture Points;
Animals;
Electroacupuncture;
Female;
Fetal Growth Retardation/therapy*;
Lung;
Pregnancy;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Acupuncture & Moxibustion
2021;41(4):405-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effect of electroacupuncture (EA) at "Zusanli" (ST 36) in pregnant rats on lung dysplasia of newborn rats with intrauterine growth restriction (IUGR) induced by maternal food restriction.
METHODS:Twenty-four female SD rats were randomly divided into a control group, a control+EA group, a model group and a model+EA group, 6 rats in each group. From the 10th day into pregnancy to the time of delivery, the rats in the model group and the model+EA group were given with 50% dietary restriction to prepare IUGR model. From the 10th day into pregnancy to the time of delivery, the rats in the control+EA group and the model+EA group were treated with EA at bilateral "Zusanli" (ST 36), once a day. The body weight of offspring rats was measured at birth, and the body weight and lung weight of offspring rats were measured on the 21st day after birth. The lung function was measured by small animal lung function detection system; the lung tissue morphology was observed by HE staining; the content of peroxisome proliferator activated receptor γ (PPARγ) in lung tissue was detected by ELISA.
RESULTS:Compared with the control group, the body weight at birth as well as the body weight, lung weight, lung dynamic compliance (Cdyn) and PPARγ at 21 days after birth in the model group were significantly decreased (
CONCLUSION:EA at "Zusanli" (ST 36) may protect the lung function and lung histomorphology changes by regulating the level of PPARγ of lung in IUGR rats induced by maternal food restriction.
