Influence of electroacupuncture on the expression of AMPA receptor subunit GluR1 in the spinal injured area of the rats with acute spinal cord injury.
10.13703/j.0255-2930.20200317-k0005
- Author:
Wen-Ci CHEN
1
;
Chu-Yong LIN
1
;
Jing JI
1
;
Wen-Zhan TU
2
;
Song-He JIANG
2
Author Information
1. Department of Rehabilitation Medicine, Wenzhou Integrated Chinese and Western Medicine Hospital of Zhejiang Chinese Medical University, Wenzhou 325027, China.
2. Department of Physical Medicine and Rehabilitation, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province.
- Publication Type:Journal Article
- Keywords:
GluR1 subunit;
acute spinal cord injury;
electroacupuncture;
glutamate excitotoxicity;
receptor, AMPA
- MeSH:
Animals;
Electroacupuncture;
Rats;
Rats, Sprague-Dawley;
Receptors, AMPA/genetics*;
Spinal Cord;
Spinal Cord Injuries/therapy*
- From:
Chinese Acupuncture & Moxibustion
2021;41(3):307-312
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the influence of electroacupuncture (EA) on the expression of AMPA receptor subunit GluR1 in the rats with acute spinal cord injury (SCI) and explore the potential effect mechanism of EA in treatment of acute SCI.
METHODS:A total of 80 SD rats were randomly divided into five groups, i.e. a sham-operation group, a model group, an AMPA antagonist (DNQX) group, an EA group and a DNQX+EA group, 16 rats in each group. The modified Allen's impacting method was adopted to prepare the rat model of acute SCI at T
RESULTS:Compared to the sham-operation group in 6 h, 24 h and 48 h after modeling, the BBB scores were all significantly decreased in the model group (
CONCLUSION:The intervention with EA at "Dazhui" and "Mingmen" promotes the repair of the injured nerve in the spinal anterior horn probably through inhibiting GluR1 expression in the spinal injured area in the rats with acute SCI.
