Effect of acupuncture on vascular endothelial function in patients of polycystic ovary syndrome with different glucose tolerance status.
10.13703/j.0255-2930.20200110-k0007
- Author:
Jun-Xin ZHANG
1
;
Xiu-Mi YOU
1
;
Juan YANG
1
;
Ying LIU
1
;
Shan HUANG
1
;
Qiu-Ping LIN
1
;
Jin-Bang XU
1
Author Information
1. Department of TCM, Fujian Maternal and Child Health Hospital Affiliated to Fujian Medical University, Fuzhou 350001, China.
- Publication Type:Journal Article
- Keywords:
acupuncture;
asymmetric dimethylarginine (ADMD);
endothelin-1 (ET-1);
impaired glucose tolerance;
insulin resistance;
malondialdehyde (MDA);
nitric oxide (NO);
polycystic ovary syndrome
- MeSH:
Acupuncture Therapy;
Blood Glucose;
Female;
Glucose;
Glucose Intolerance/therapy*;
Humans;
Insulin;
Insulin Resistance;
Polycystic Ovary Syndrome/therapy*
- From:
Chinese Acupuncture & Moxibustion
2021;41(2):155-160
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of acupuncture on vascular endothelial function in patients of polycystic ovary syndrome (PCOS) with impaired glucose tolerance (IGT) and normal glucose tolerance (NGT).
METHODS:A total of 140 patients with PCOS were divided into an IGT group (70 cases, 11 dropped off) and a NGT group (70 cases, 9 cases dropped off). The patients in the two groups were treated with full-cycle acupuncture at Zhongwan (CV 12), Guanyuan (CV 4), Qihai (CV 6), Tianshu (ST 25), etc. once every other day, 3 times a week, for 3 months. Before and after treatment, TCM symptom score, insulin resistance index [including fasting plasma glucose (FPG), 2-hour blood glucose (2hPG), fasting serum insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR)] and vascular endothelial related factors [including asymmetric dimethylarginine (ADMD), endothelin-1 (ET-1), malondialdehyde (MDA), nitric oxide (NO)] were compared between the two groups; in addition, the obese subgroup and non-obese subgroup of the two groups were further compared.
RESULTS:Compared before treatment, the TCM symptom scores, ADMD, ET-1 and MDA after treatment were decreased (
CONCLUSION:Acupuncture could improve vascular endothelial function in PCOS patients, IGT patients have better efficacy than NGT patients, and obese patients have better efficacy than non-obese patients.
