Effect of acupuncture-moxibustion on negative emotions and plasma tryptophan metabolism in patients with Crohn's disease at active stage.
10.13703/j.0255-2930.20200814-k0003
- Author:
Chun-Hui BAO
1
;
Jie ZHONG
2
;
Hui-Rong LIU
1
;
Yu-Pei GU
2
;
Pin WU
3
;
Kan GU
3
;
Di WANG
3
;
Zhi-Jun WENG
1
;
Yin SHI
1
;
Huan-Gan WU
1
Author Information
1. Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of TCM, Shanghai 200030, China.
2. Digestion Department of Ruijin Hospital Affiliated to Shanghai Jiaotong University.
3. Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrative Chinese and Western Medicine Affiliated to Shanghai University of TCM.
- Publication Type:Randomized Controlled Trial
- Keywords:
Crohn's disease;
acupuncture and moxibustion;
negative emotions;
randomized controlled trial (RCT);
tryptophan
- MeSH:
Acupuncture Points;
Acupuncture Therapy;
Crohn Disease/therapy*;
Emotions;
Humans;
Moxibustion;
Plasma;
Treatment Outcome;
Tryptophan
- From:
Chinese Acupuncture & Moxibustion
2021;41(1):17-22
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of acupuncture-moxibustion on negative emotions and plasma tryptophan (Trip)-kynurenine (Kyn) metabolism in the patients with Crohn's disease (CD) at the mild and moderate active stage.
METHODS:A total of 66 CD patients were randomized into an observation group (33 cases, 1 case dropped off) and a control group (33 cases, 2 cases dropped off). In the observation group, acupuncture was applied in combination with moxibustion. In the control group, the sham-acupuncture was used in combination with sham-moxibustion. In both of the observation group and the control group, acupuncture was applied to Zhongwan (CV 12), Shangjuxu (ST 37), Sanyinjiao (SP 6), Gongsun (SP 4), Hegu (LI 4), Quchi (LI 11), Taixi (KI 3) and Taichong (LR 3), and moxibustion was applied to Tianshu (ST 25) and Zusanli (ST 36). The treatment was given once every two days, 3 times a week, totally for 12 weeks. Separately, before and after treatment, the score of the hospital anxiety-depression scale (HADS) and the score of intestinal core symptoms (degree of abdominal pain and frequency of diarrhea) were observed in the patients of the two groups. The concentration of plasma indoleamine 2,3-dioxygenase 1 (IDO1) and the ratios of Kyn/Trp, QuinA/Kyn, KynA/Kyn and KynA/QuinA were compared between the two groups.
RESULTS:Compared with before treatment, the scores of HADS-A and HADS-D in the observation group and the score of HADS-A in the control group were all reduced after treatment (
CONCLUSION:Acupuncture and moxibustion relieve the negative emotions of anxiety and depression in CD patients at mild and moderate active stage, which is probably related to the regulation of plasma Trp-Kyn metabolic pathway.
