Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats.
10.13703/j.0255-2930.20191012-k0004
- Author:
Chuan HE
1
;
Zhong-Sheng HUANG
1
;
Hong-Ru CHEN
1
;
Chao-Chao YU
1
;
Xue-Song WANG
1
;
Tao JIANG
1
;
Li-Hong KONG
1
Author Information
1. College of Acupuncture-Moxibustion and Orthopedics, Hubei University of CM, Wuhan 430061, China.
- Publication Type:Journal Article
- Keywords:
Alzheimer's diseasea;
Caspase-1a;
hippocampus;
interleukin 1β (IL-1β)a;
learning-memory abilitya;
microglia (MG)a;
nucleotide-binding oligomerization domain-like receptor 3 (NLRP3)a;
pretreatment of acupuncturea
- MeSH:
Alzheimer Disease/therapy*;
Animals;
Electroacupuncture;
Hippocampus;
Inflammasomes;
NLR Family, Pyrin Domain-Containing 3 Protein/genetics*;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Acupuncture & Moxibustion
2020;40(12):1323-1327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(NLRP3), Caspase-1, interleukin1β(IL-1β) and the number of activated microglia (MG) in the hippocampus in Alzheimer's disease (AD) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating AD.
METHODS:A total of 36 SD rats were randomly divided into a blank group, a model group and an electroacupuncture (EA) group, 12 rats in each group. The AD like rat model was established by 8-week continuous intraperitoneal injection of D-galactose (120 mg·kg
RESULTS:Compared with the blank group, the average escape latency was prolonged (
CONCLUSION:Pretreatment of acupuncture could prevent and treat the learning-memory dysfunction in AD like rats, and its mechanism may be related to the inhibition of NLRP3 inflammatsome related protein and MG activation.
