Role of the JAK/STAT/SOCS signaling pathway in hepatitis B virus-related liver diseases
10.3969/j.issn.1001-5256.2021.06.045
- VernacularTitle:JAK/STAT/SOCS信号通路在HBV相关肝脏疾病中的作用
- Author:
Yujuan PENG
1
;
Jing YOU
;
Jing LI
;
Guangjun TANG
Author Information
1. 1. Department of Infectious Diseases and Hepatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Research Article
- Keywords:
Hepatitis B virus;
Liver Diseases;
Signal Transduction
- From:
Journal of Clinical Hepatology
2021;37(6):1435-1439
- CountryChina
- Language:Chinese
-
Abstract:
The JAK/STAT/SOCS signaling pathway can mediate a variety of cytokines involved in inflammation, tumor, and autoimmune diseases and it also plays an important role in hepatitis B virus (HBV) infection-related liver diseases. This article briefly reviews the structure and signal pathway regulation of JAK-STAT and SOCS and elaborates on their role in the development and progression of HBV-related chronic hepatitis B, liver cirrhosis, liver failure, and hepatocellular carcinoma. The final analysis shows that the JAK/STAT/SOCS signaling pathway is dysregulated in HBV-related liver disease and is involved in the development and progression of the disease, and it may even influence the treatment and prognosis of the disease.
