The study of intermediate-term survival of the patients with cerebral venous sinus thrombosis

Afshin Borhani-haghighi; Soroush Ghannadi; Anahid Safari; Mojtaba Neydavoudi; Maryam Poursadeghfard; Nahid Ashjazadeh; Etrat Hooshmandi

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The study of intermediate-term survival of the patients with cerebral venous sinus thrombosis

Author: Afshin Borhani-Haghighi ¹ ; Soroush Ghannadi ² ; Anahid Safari ³ ; Mojtaba Neydavoudi ¹ ; Maryam Poursadeghfard ¹ ; Nahid Ashjazadeh ¹ ; Etrat Hooshmandi ¹
Author Information

1. Clinical Neurology Research Center,Shiraz University of Medical Sciences, Shiraz, Iran
2. Soroush Ghannadi, Shiraz University of Medical Sciences, Shiraz, Iran
3. Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Publication Type:Journal Article
Keywords: Cerebral venous sinus thrombosis; age; intermediate survival; mortality
From:Neurology Asia 2020;25(4):453-457
CountryMalaysia
Language:English
Abstract: Objective: This study aimed to investigate the intermediate survival of patients with cerebral venous sinus thrombosis (CVST). Methods: This is a retrospective study recruiting patients with a definite diagnosis of CVST who were referred to teaching hospitals of “Shiraz University of Medical Sciences” from 2007 to 2017. Follow-up phone calls were conducted in March 2019 till June 2019. All-cause mortality, mortality due to CVST, and CVST recurrence were investigated. Results: Of the total of 301 patients, 213 (70.8%) were female. Patients’ age ranged from 1 to 95 year with a mean of 39.9 year. Intermediate follow-up (mean 46.9, 95%CI: 43.6-50.2 months) was done. Intermediate term mortality was 12.3%, mostly from CVST, and largely occurred within the first month. Age was a significant risk factor for survival (HR=1.056, 95%CI:1.037-1.075). The difference was not statistically significant in males in comparison to females (HR=1.3, 95%CI:0.67-2.60, P=0.41). Patients with recurrent CVST hada higher risk of mortality (HR=9.14, 95%CI:4.70-17.89, P<0.001). There was statistically higher risk of mortality in patients with deep vein thrombosis (DVT) (HR=8.97, 95%CI: 4.32-18.61, P<0.001). Although the risk of death for patients using oral contraceptives (OCPs) was 16% higher, this was not statistically significant (HR=1.16, 95%CI: 0.52-2.55, P= 0.21). Conclusions: Intermediate-term mortality was 12.3%, and associated with older age, recurrent CVST and DVT. The reasons for these findings need further investigation.
Full text:7.2020my0066.pdf