Auraptene has neuroprotective and memory enhancing effects in a rat model of Alzheimer’s disease

Sadri Joghataee; Mohammad Mohammad-zadeh; Bahareh Amin; Faranak Jafari; Mahdi Tondar; Omid Gholami

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Auraptene has neuroprotective and memory enhancing effects in a rat model of Alzheimer’s disease

Author: Sadri Joghataee ¹ ; Mohammad Mohammad-zadeh ² ; Bahareh Amin ² ; Faranak Jafari ³ ; Mahdi Tondar ⁴ ; Omid Gholami ²
Author Information

1. Student Research Committee and
2. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar
3. Department of Physiology and School of Paramedical Sciences, 4 Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
4. Cedars Sinai Medical Center, Los Angeles, CA.
Publication Type:Journal Article
Keywords: Spatial memory; auraptene; rat/Wistar; bax protein
From:Neurology Asia 2020;25(3):353-360
CountryMalaysia
Language:English
Abstract: Background: Auraptene is a simple coumarin that exhibits multiple protective activities in the brain. Alzheimer’s disease is a complex, multifactorial, and progressive neurodegenerative disease. Microinjection of the β-amyloid peptide (Aβ) into the hippocampus of rat has been recognized as a reliable and stable animal model of Alzheimer’s disease, which mimics the memory deficits. In the present study, the memory enhancing effects of auraptene were studied in rats that Aβ was injected into their hippocampus to create a model of Alzheimer’s disease. Methods: Different doses of auraptene (5, 10 and 25 mg/kg) were administered intraperitoneally to male Wistar rats. The spatial memory performance was tested by Morris water maze after Alzheimer`s induction. The hippocampal expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins were calculated for evaluating the neuroprotective and anti-apoptotic effects of Auraptene in the brain tissue. Results: In comparison with the control group, auraptene significantly decreased the escape latency time in the treated rats. In addition, auraptene increased the percentage of time spent and traveled pathway in the target quadrant. Molecular data showed that auraptene attenuated the Bax/Bcl-2 ratio in the hippocampus of rats. Conclusion: This study demonstrated the memory enhancing effect of Aur after Aβ injection, which could be through inhibiting the apoptotic pathways in the hippocampus of rats.
Full text:7.2020my0052.pdf