Research and development concept of barrier membranes based on “ immune microenvironment regulation”
10.12016/j.issn.2096-1456.2021.08.001
- Author:
CHEN Zetao
1
;
LIN Yixiong
1
;
YANG Jieting
2
;
HUANG Baoxin
2
;
CHEN Zhuofan
3
Author Information
1. Laboratory of Stomatology/ Institute of Stomatology and Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering
2. Institute of Stomatology and Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology
3. Zhujiang New Town Clinic, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology
- Publication Type:Journal Article
- Keywords:
barrier membrane;
immune microenvironment;
osteogenic differentiation;
bone regeneration;
foreign body reaction;
degradation;
immune cells;
macrophage
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(8):505-514
- CountryChina
- Language:Chinese
-
Abstract:
Guided bone regeneration technology applied in alveolar bone defect regeneration is based on the barrier function and space maintenance of the barrier membrane. Therefore, traditional development strategies for barrier membranes focus on their physical barrier function, degradation characteristics and biocompatibility to avoid immunogenicity. However, not only does the barrier membrane passively block connective tissue, it is recognized as a “foreign body”that triggers a persistent host immune response, known as a foreign body reaction. The theories of osteoimmunology reveal a close relationship between the immune system and bone system and emphasize the role of immune cells in bone tissue-related pathophysiological processes. Based on these findings, we propose a novel development strategy for barrier membranes based on immune microenvironment regulation: by manipulating mechanical properties, surface properties and physiochemical properties, barrier membranes are endowed with an improved immunomodulation ability, which helps to regulate immune cell reactions to induce a favorable local immune microenvironment, thus coordinating osteogenesis and osteoclastogenesis as well as barrier membrane degradation to increase the efficiency of barrier membranes in GBR applications. In this paper, we review the development of barrier membranes and their close relationship to the immune microenvironment concerning bone regeneration and membrane degradation. Additionally, the outcomes of research on barrier membranes based on the regulation of the immune microenvironment have been summarized to improve the osteogenesis efficiency of barrier membranes and solve the problem of the regeneration and repair of bone defects, especially alveolar bone defects.
- Full text:基于“免疫微环境调控”的屏障膜研发理念.pdf
