The Effect of Ginkgo Biloba Extract (Ginexin(R)) on Experimental Central Retinal Vein Occlusion.
- Author:
Kyung Sik CHOI
1
;
Hyeong Gon YU
;
Ju Hyun KIM
;
Su Jung SONG
;
Young Ju KIM
;
Young Suk YU
;
Hum CHUNG
Author Information
1. Department of Ophthalmology, College of Medicine, SoonchunHyang University, Korea.
- Publication Type:Original Article
- Keywords:
Ginkgo biloba;
Ischemic retina;
Vein occlusion
- MeSH:
Animals;
Argon;
Carboxymethylcellulose Sodium;
Fluorescein;
Fluorescein Angiography;
Ginkgo biloba*;
Glutamic Acid;
Ophthalmoscopy;
Rats;
Reperfusion;
Retina;
Retinal Ganglion Cells;
Retinal Vein Occlusion;
Retinal Vein*;
Rose Bengal;
Veins
- From:Journal of the Korean Ophthalmological Society
2004;45(5):832-839
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the beneficial effect of ginkgo biloba (Ginexin(R)) on ischemic retina model by retinal vein occlusion after photodynamic injury. METHODS: Ginkgo biloba 20 mg/kg/day, 100 mg/kg/day or carboxymethyl cellulose as a control group was administrated orally from 1week before the retinal vein occlusion to 2weeks after. After rose bengal was injected through vein of tail, retinal vein was occluded with argon laser. And then venous occlusion was confirmed by fluorescein angiogram. Rats were examined by using an indirect ophthalmoscopy and fluorescein angiography to detect reperfusion and new vessels. Eyeballs were enucleated for histological examination, retinal ganglion cell count and intravitreal glutamate level. RESULTS: The reperfusion of occluded vein was faster in the ginkgo biloba-treated group than the control group. In the ginkgo biloba-treated group, damage of the inner retina and TUNEL-positive cells were smaller than the control group on histologic examination. The concentration of retinal ganglion cells in the control group was lower than in the ginkgo biloba-treated group. CONCLUSIONS: Ginkgo biloba has protective effects in experimental ischemic retina after vein occlusion.
