Bcl-2 and Bax Expression and Ki-67 Proliferative Index in Astrocytic Tumors: in Relation to Prognosis.
- Author:
Sei Yoon KIM
1
;
Soon Hee CHUNG
;
Hun Joo KIM
;
Kum WHANG
;
Young Pyo HAN
;
Soon Ki HONG
Author Information
1. Department of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Astrocytic tumor;
Bcl-2;
Bax;
Ki-67;
Prognostic factor
- MeSH:
Coloring Agents;
Kaplan-Meier Estimate;
Prognosis*;
Retrospective Studies
- From:Journal of Korean Neurosurgical Society
2004;35(5):465-471
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors. METHODS: We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl-2, bax and Ki-67. RESULTS: The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%). However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05). CONCLUSION: Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors.
