Correlation study between four vessel regulate factors and white finger evaluating in workers exposed to hand-arm vibration
10.11763/j.issn.2095-2619.2016.03.005
- Author:
Li LANG
1
;
Han-Sheng LIN
1
;
Qing-Song CHEN
1
;
Bin XIAO
1
;
Ying ZHANG
1
;
Fan-Song ZENG
1
Author Information
1. Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou,Guangdong 510300,China
- Publication Type:Journal Article
- Keywords:
Hand-arm vibration;
Vibration-induced white finger;
Vascular damage;
Endothelin;
Transforming growth factor;
Soluble intercellular adhesion molecule;
5-Hydroxytryptamine
- From:
China Occupational Medicine
2016;43(03):269-274
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To analyze the correlation between four vessel regulate factors and vibration-induced white finger( VWF) evaluating in workers exposed to hand-arm vibration,and discuss the value of regulate factors for VWF screening.METHODS: Using typical sampling method,77 male workers exposed to hand-arm vibration with more than 1 year of polish work from a metalwork factory were selected as the study subjects. Based on the workers' self-report,they were divided into VWF group( 43 workers) and non-VWF group( 34 workers). The venous blood from center elbow was collected and plasma was separated. The plasma level of endothelin( ET) was detected by radioimmunoassay. The plasma levels of transforming growth factor beta( TGF-β),soluble intercellular adhesion molecule-1( s ICAM-1) and 5-hydroxytryptamine( 5-HT) were detected by enzyme-linked immunosorbent assay. The regulate factors for evaluating VWF were screened and the new multivariable model index ^y was built by logistic regression. The related factors were analyzed according to the receiver operating characteristic( ROC) curve. RESULTS: Compared with the non-VWF group,the plasma level of ET in VWF group was decreased( P < 0. 01),and the plasma level of TGF-β was increased( P < 0. 01). Both the levels of s ICAM-1 and 5-HT between the two groups showed no significant difference( P > 0. 05). The logistic regression analysis results showed that after adjusting the confounding factors of age,smoking,alcohol and symptoms in hands,there was a negative correlation found between the ET plasma level and VWF( P < 0. 01) and a positive correlation between the TGF-βplasma level and VWF( P < 0. 01). The VWF incidence was not correlated with plasma levels of s ICAM-1 and 5-HT( P >0. 05). According to ROC curve analysis,the area under the curve( AZ) value of the plasma levels of ET and TGF-β were0. 787 and 0. 691,respectively( P < 0. 01); the sensitivity were 70. 60% and 53. 49%,and the specificity were 79. 10%and 85. 29% respectively. The multivariable model index ^y built with ET and TGF-β by logistic regression was used to judge the AZvalue of VWF to be 0. 821( P < 0. 01),with the 72. 09% of sensitivity and 76. 47% of specificity. The AZ values among ET and TGF-β,^y and ET showed no statistical significance( P > 0. 05). The AZvalue of ^y was larger than that of TGF-β( P < 0. 05). CONCLUSION: The plasma levels of ET and TGF-β are correlation with VWF in hand-arm vibration exposure workers,which can be used in the reseach of screening VWF. The correlation between VWF and SICAM as well as 5-HT needs to be further research.
