Correlation analysis between serum and bronchoalveolar lavage fluid TNF-α and the lung function of coal workers' pneumoconiosis
10.11763/j.issn.2095-2619.2016.01.009
- Author:
Wei GUO
1
;
Ping WANG
;
Hua-Min YANG
;
Feng-Ling ZHAO
;
Yu-Min L
;
Han-Lin HUANG
;
Jing WANG
1
Author Information
1. The First Affiliated Hospital of Zhengzhou University Zhengzhou,Henan 450052,China
- Publication Type:Journal Article
- Keywords:
Coal workers' pneumoconiosis;
Serum;
Bronchoalveolar lavage fluid;
Tumor necrosis factor-α;
Lung function
- From:
China Occupational Medicine
2016;43(01):48-51
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the effect and significance of tumor necrosis factor-α( TNF-α) in serum and bronchoalveolar lavage fluid( BALF) of coal workers' pneumoconiosis( CWP). METHODS: Twenty-eight cases of CWP were selected by purposive sampling method and divided into 3 groups based on different stages of pneumoconiosis. There were 7 cases in stage Ⅰ,10 cases in stage Ⅱ,and 11 cases in stage Ⅲ. The venous blood and BALF were collected.TNF-α in the serum and BALF were detected by chemiluminescence assay. The lung function was determined. RESULTS: In the serum,the TNF-α level of CWP patients was positively correlated with the CWP stage [Spearman correlation coefficient( rS) = 0. 843,P < 0. 01],and negatively correlated with the forced expiratory volume in one second/forced vital capacity( FEV1/ FVC)( rS=- 0. 503,P < 0. 01). In BALF,the TNF-α level of CWP patients was negatively correlated with the CWP stage( rS=- 0. 654,P < 0. 01),and positively correlated with the FEV1/ FVC( rS= 0. 432,P <0. 05). The TNF-α level in the serum was negatively correlated with the TNF-α level in BALF( rS=- 0. 561,P < 0. 01).CONCLUSION: With the development of pneumoconiosis,the levels of TNF-α in the serum and BALF showed different variation,and were correlated with the changes of FEV1/ FVC. The level of TNF-α could be used as a reference index for evaluating the severity of CWP.
