Network Meta-analysis on efficacy and safety of non-steroidal anti-inflammatory drugs for osteoarthritis in middle aged and old people
10.12206/j.issn.1006-0111.202101022
- VernacularTitle:非甾体抗炎药治疗我国中老年骨关节炎疗效和安全性的网状Meta分析
- Author:
Bin SUN
1
;
Zijing WANG
2
,
3
;
Yang CAO
2
,
3
;
Rui MENG
2
,
3
;
Lan YANG
2
,
3
;
Jinbao ZHU
3
Author Information
1. Department of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China.
2. a. School of International Pharmaceutical Business, 2b. Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing 211198, China
3. a. School of International Pharmaceutical Business, 2b. Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing 211198, China.
- Keywords:
osteoarthritis;
middle-aged to old;
non-steroidal anti-inflammatory drugs;
network Meta-analysis
- From:
Journal of Pharmaceutical Practice
2021;39(3):259-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of different non-steroidal anti-inflammatory drugs (NSAIDs) in middle-aged and old Chinese patients with osteoarthritis(OA). Methods A systematic literature search was conducted through PubMed, Cochrane Library, CNKI, Wan Fang Data and VIP databases to collect randomized controlled trials with non-steroidal anti-inflammatory drugs in middle-aged to old Chinese OA patients. The search time was from the establishment of the database to November 17, 2020. Two researchers independently carried out literature screening, data extraction and literature quality evaluation. Bayesian network meta-analysis was conducted with R3.6.0 software. Results 28 RCTs were included with 2531 patients. Based on the last follow-up pain visual analogue scale (VAS) score, the ranking chart showed that Etoricoxib had the highest probability of having the lowest pain VAS score (88.55%). In terms of total effective rate, the ranking chart showed that the probability of Etoricoxib as first choice was the highest (92.49%). As far as safety, diclofenac sodium patch had the lowest adverse effects rate (59.10%). Conclusion The results of this study indicated that Etoricoxib was the most effective treatment for middle-aged and old Chinese OA patients. It can significantly reduce the OA pain. Diclofenac sodium patch had the least adverse effects.
