Study on the antifungal activity of phenazine derivatives
10.12206/j.issn.1006-0111.202103083
- VernacularTitle:吩嗪类衍生物的抗真菌活性研究
- Author:
Lijuan QIU
1
;
Wen CHAO
1
;
Anjie SHI
2
;
Lan YAN
2
;
Quanzhen LÜ
2
;
Yuanying JIANG
2
Author Information
1. Basic Medicine School.
2. College of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
phenazine derivatives;
Candida albicans;
antifungal activity;
hyphae formation
- From:
Journal of Pharmaceutical Practice
2021;39(3):249-254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antifungal activity of phenazines derivatives. Methods The anti-fungal activity of phenazine compounds was evaluated initially with micro-liquid dilution. No significant antifungal activity against Candida albicans was found. Then, with the combination of phenazine compounds and fluconazole, the anti-fungal activity against fluconazole-resistant C. albicans was detected. Results The phenazine-17 had significant antifungal activity when combined with fluconazole through the inhibition of hyphae formation. Conclusion This study provides a new idea for the development of antifungal drugs and the solution of antifungal drug resistance.
