Protective effect of Shengxian decoction and the decoction of single herb component against myocardial injury induced by hypoxia/reoxygenation
10.12206/j.issn.1006-0111.202006080
- VernacularTitle:升陷汤及单味药材水提物对缺氧/复氧致心肌损伤的保护作用
- Author:
Xiaoling JIN
1
;
Lan CHEN
2
;
Feng ZHANG
1
;
Doudou HUANG
1
;
Lina LIAO
1
;
Wansheng CHEN
3
,
4
Author Information
1. Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.
2. Department of Drug and Equipment, Air Force Hangzhou Special Service Recuperation Center Sanatorium Area,Hangzhou 310002, China.
3. Department of Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
4. Traditional Chinese Medicine Resource and Technology Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Keywords:
Shengxian decoction;
hypoxia/reoxygenation injury;
cardiomyocyte;
protection effect
- From:
Journal of Pharmaceutical Practice
2021;39(3):240-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of Shengxian decoction and the single herb decoction against myocardial injury induced by hypoxia/reoxygenation. Methods The H9c2 cells were cultured to establish hypoxia/reoxygenation model. Rats were divided into 8 groups: normal control group, hypoxia/reoxygenation group (model group) and treated groups (Shengxian decoction and the single herb decoction). The apoptotic rate of cardiomyocytes, the activity of reactive oxygen species (ROS) and intracellular calcium concentration (Ca2+) were measured. Results Compared with hypoxia/reoxygenation group, the apoptosis rate, ROS activity and intracellular Ca2+ concentration were significantly lower in all treated groups (P<0.05). The ROS activity and intracellular Ca2+ concentration was decreased by 41.37% and 15.20% in Shengxian decoction group compared to the model group. Conclusion Shengxian decoction and the single herb decoction had protective effect on myocardial injury induced by hypoxia/reoxygenation.
