Anti-inflammatory and analgesic activity analysis of Yinlian Tongfeng granules based on network Pharmacology
10.12206/j.issn.1006-0111.202007014
- VernacularTitle:基于网络药理学对茵连痛风颗粒抗炎镇痛作用的机制研究
- Author:
Yi XU
1
;
Jing LIU
1
;
Jin HUANG
1
;
Jingang CUI
2
Author Information
1. Department of Pharmacy, Yueyang Hospital of Integrated Traditional and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437.
2. Clinical Research Institute of Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200437.
- Keywords:
Yinlian Tongfeng granules;
anti-inflammatory and analgesic activity;
network pharmacology
- From:
Journal of Pharmaceutical Practice
2021;39(3):226-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the anti-inflammatory and analgesic mechanism of Yinlian Tongfeng granules by network pharmacology. Methods Three main active components of Yinlian Tongfeng granules were collected from TCMSP database to predict its effective targets. Based on the network information of active components and targets, the anti-inflammatory and analgesic related targets were established by using protein-protein interaction information. The enrichment analysis of KEGG biological pathway and go function enrichment were carried out to construct the active component-target-signal pathway network and explain the main mechanism of anti-inflammatory and analgesic. Results 37 targets were closely related to anti-inflammation and analgesic effects of Yinlian Tongfeng granules, mainly on Prostaglandin endoperoxide synthase 2(PTGS2), interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factors (TNF). The mechanism of action may relate to the regulation of nuclear transcription factor B signaling pathway(NF-κB). Conclusion The study predicted the anti-inflammatory and analgesic mechanism of Yinlian Tongfeng granules, and provided theoretical basis for further verification and interpretation of its mechanism.
